- Appendix AI Administrative Instructions Under the PCT

Go to MPEP - Table of Contents

Notice regarding Section 508 of the Workforce Investment Act of 1998. Section 508 of the Workforce Investment Act of 1998 requires all United States Federal Agencies with websites to make them accessible to individuals with disabilities. At this time, the MPEP files below do not meet all standards for web accessibility. Until changes can be made to make them fully accessible to individuals with disabilities, the USPTO is providing access assistance via telephone. MPEP Interim Accessibility Contact: 571-272-8813.

browse before

- Appendix AI Administrative Instructions Under the PCT

Appendices
Appendix 1: Numeric Identifiers
Appendix 2: Nucleotide and Amino Acid Symbols and Feature Table

Table 1: List of Nucleotides

Table 2: List of Modified Nucleotides

Table 3: List of Amino Acids

Table 4: List of Modified and Unusual Amino Acids

Table 5: List of Feature Keys Related to Nucleotide Sequences

Table 6: List of Feature Keys Related to Protein Sequences

Appendix 3: Specimen Sequence Listing
[Appendices 1 to 3 to Annex C follow]
Annex C, Appendix 1
Numeric Identifiers
Only numeric identifiers as defined below may be used in sequence listings submitted in applications. The text of the data element headings given below shall not be included in the sequence listings.
Numeric identifiers of mandatory data elements, that is, data elements which must be included in all sequence listings (see paragraph 25 of this Standard: items 110, 120, 160, 210, 211, 212, 213 and 400) and numeric identifiers of data elements which must be included in circumstances specified in this Standard (see paragraphs 26, 27, 28, 29 and 30 of this Standard: items 130, 140, 141, 150 and 151, and 220 to 223) are marked by the symbol "M."
Numeric identifiers of optional data elements (see paragraph 31 of this Standard) are marked by the symbol "O."

Numeric Identifier Numeric Identifier Description Mandatory (M) or Optional (O) Comment

<110> Applicant name M where the name of the applicant is written in characters other than those of the Latin alphabet, the same shall also be indicated in characters of the Latin alphabet either as a mere transliteration or through translation into English

<120> Title of Invention M

<130> File Reference M, in the circumstances specified in paragraph 26 of this Standard see paragraph 26 of this Standard

<140> Current patent application M, in the circumstances specified in paragraph 27 of this Standard see paragraph 27 of this Standard; the current patent application shall be identified, in the following order, by the two-letter code indicated in accordance with WIPO Standard ST.3 and the application number (in the format used by the industrial property Office with which the current patent application is filed) or, for an international application, by the international application number

<141> Current filing date M, in the circumstances specified in paragraph 27 of this Standard see paragraph 27 of this Standard; the date shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)

<150> Earlier patent application M, in the circumstances specified in paragraph 28 of this Standard see paragraph 28 of this Standard; the earlier patent application shall be identified, in the following order, by the two-letter code indicated in accordance with WIPO Standard ST.3 and the application number (in the format used by the industrial property Office with which the earlier patent application was filed) or, for an international application, by the international application number

<151> Earlier application filing date M, in the circumstances specified in paragraph 28 of this Standard see paragraph 28 of this Standard; the date shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)

<160> Number of SEQ ID NOs M

<170> Software O

<210> Information for SEQ ID NO: x M response shall be an integer representing the SEQ ID NO shown

<211> Length M sequence length expressed in number of base pairs or amino acids

<212> Type M type of molecule sequenced in SEQ ID NO: x, either DNA, RNA or PRT; if a nucleotide sequence contains both DNA and RNA fragments, the value shall be "DNA"; in addition, the combined DNA/RNA molecule shall be further described in the <220> to <223> feature section

<213> Organism M Genus Species (that is, scientific name) or "Artificial Sequence" or "Unknown"

<220> Feature M, in the circumstances specified in paragraph 29 and 30 of this Standard leave blank; see paragraphs 29 and 30 of this Standard; description of points of biological significance in the sequence in SEQ ID NO: x) (may be repeated depending on the number of features indicated)

<221> Name/key M in the circumstances specified in paragraph 29 of this Standard see paragraph 29 of this Standard; only those keys as described in Table 5 or 6 of Appendix 2 shall be used

<222> Location M, in the circumstances specified in paragraph 29 of this Standard see paragraph 29 of this Standard; - from (number of first base/amino acid in the feature) - to (number of last base/amino acid in the feature) - base pairs (numbers refer to positions of base pairs in a nucleotide sequence) - amino acids (numbers refer to positions of amino acid residues in an amino acid sequence) - whether feature is located on the complementary strand to that filed in the sequence listing

<223> Other information: M, in the circumstances specified in paragraphs 29 and 30 of this Standard see paragraphs 29 and 30 of this Standard; any other relevant information, using language neutral vocabulary, or free text (preferably in English); any free text is to be repeated in the main part of the description in the language thereof (see paragraph 36 of this Standard); where any modified base or modified/unusual L-amino acid appearing in Appendix 2, Tables 2 and 4, is in the sequence, the symbol associated with that base or amino acid from Appendix 2, Tables 2 and 4, should be used

<300> Publication information O leave blank; repeat section for each relevant publication

<301> Authors O

<302> Title O title of publication

<303> Journal O journal name in which data published

<304> Volume O journal volume in which data published

<305> Issue O journal issue number in which data published

<306> Pages O journal page numbers on which data published

<307> Date O journal date on which data published; if possible, the date shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)

<308> Database accession number O accession number assigned by database including database name

<309> Database entry date O date of entry in database; the date shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)

<310> Document number O document number, for patent type citations only; the full document shall specify, in the following order, the two-letter code indicated in accordance with WIPO Standard ST.3, the publication number indicated in accordance with WIPO Standard ST.6, and the kind-of-document code indicated in accordance with WIPO Standard ST.16

<311> Filing date O document filing date, for patent-type citations only; the date shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)

<312> Publication date O document publication date; for patent-type citations only; the date shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)

<313> Relevant residues in SEQ ID NO: x: from to O

<400> Sequence M SEQ ID NO: x should follow the numeric identifier and should appear on the line preceding the sequence (see Appendix 3)

Annex C, Appendix 2
Nucleotide and Amino Acid Symbols and Feature Table

Table 1: List of Nucleotides

Symbol Meaning Origin of designation

a a a denine

g g g uanine

c c c ytosine

t t t hymine

u u u racil

r g or a pu r ine

y t/u or c p y rimidine

m a or c a m ino

k g or t/u k eto

s g or c s trong interactions 3H-bonds

w a or t/u w eak interactions 2H-bonds

b g or c or t/u not a

d a or g or t/u not c

h a or c or t/u not g

v a or g or c not t, not u

n a or g or c or t/u, unknown, or other a n y

Table 2: List of Modified Nucleotides

Symbol Meaning

ac4c 4-acetylcytidine

chm5u 5-(carboxyhydroxymethyl)uridine

cm 2'-O-methylcytidine

cmnm5s2u 5-carboxymethylaminomethyl-2-thiouridine

cmnm5u 5-carboxymethylaminomethyluridine

d dihydrouridine

fm 2'-O-methylpseudouridine

gal q beta, D-galactosylqueuosine

gm 2'-O-methylguanosine

i inosine

i6a N6-isopentenyladenosine

m1a 1-methyladenosine

m1f 1-methylpseudouridine

m1g 1-methylguanosine

m1i 1-methylinosine

m22g 2,2-dimethylguanosine

m2a 2-methyladenosine

m2g 2-methylguanosine

m3c 3-methylcytidine

m5c 5-methylcytidine

m6a N6-methyladenosine

m7g 7-methylguanosine

mam5u 5-methylaminomethyluridine

mam5s2u 5-methoxyaminomethyl-2-thiouridine

man q beta, D-mannosylqueuosine

mcm5s2u 5-methoxycarbonylmethyl-2-thiouridine

mcm5u 5-methoxycarbonylmethyluridine

mo5u 5-methoxyuridine

ms2i6a 2-methylthio-N6-isopentenyladenosine

ms2t6a N-((9-beta-D-ribofuranosyl-2-methylthiopurine-6-yl)carbamoyl)threonine

mt6a N-((9-beta-D-ribofuranosylpurine-6-yl)N-methylcarbamoyl)threonine

mv uridine-5-oxyacetic acid-methylester

o5u uridine-5-oxyacetic acid

osyw wybutoxosine

p pseudouridine

q queuosine

s2c 2-thiocytidine

s2t 5-methyl-2-thiouridine

s2u 2-thiouridine

s4u 4-thiouridine

t 5-methyluridine

t6a N-((9-beta-D-ribofuranosylpurine-6-yl)-carbamoyl)threonine

tm 2'-O-methyl-5-methyluridine

um 2'-O-methyluridine

yw wybutosine

x 3-(3-amino-3-carboxy-propyl)uridine, (acp3)u

Table 3: List of Amino Acids

Symbol Meaning

Ala Alanine

Cys Cysteine

Asp Aspartic Acid

Glu Glutamic Acid

Phe Phenylalanine

Gly Glycine

His Histidine

Ile Isoleucine

Lys Lysine

Leu Leucine

Met Methionine

Asn Asparagine

Pro Proline

Gln Glutamine

Arg Arginine

Ser Serine

Thr Threonine

Val Valine

Trp Tryptophan

Tyr Tyrosine

Asx Asp or Asn

Glx Glu or Gln

Xaa unknown or other

Table 4: List of Modified and Unusual Amino Acids

Symbol Meaning

Aad 2-Aminoadipic acid

bAad 3-Aminoadipic acid

bAla beta-Alanine, beta-Aminopropionic acid

Abu 2-Aminobutyric acid

4Abu 4-Aminobutyric acid, piperidinic acid

Acp 6-Aminocaproic acid

Ahe 2-Aminoheptanoic acid

Aib 2-Aminoisobutyric acid

bAib 3-Aminoisobutyric acid

Apm 2-Aminopimelic acid

Dbu 2,4 Diaminobutyric acid

Des Desmosine

Dpm 2,2'-Diaminopimelic acid

Dpr 2,3-Diaminopropionic acid

EtGly N-Ethylglycine

EtAsn N-Ethylasparagine

Hyl Hydroxylysine

aHyl allo-Hydroxylysine

3Hyp 3-Hydroxyproline

4Hyp 4-Hydroxyproline

Ide Isodesmosine

aIle allo-Isoleucine

MeGly N-Methylglycine, sarcosine

MeIle N-Methylisoleucine

MeLys 6-N-Methyllysine

MeVal N-Methylvaline

Nva Norvaline

Nle Norleucine

Orn Ornithine

Table 5: List of Feature Keys Related to Nucleotide Sequences

Key Description

allele a related individual or strain contains stable, alternative forms of the same gene which differs from the presented sequence at this location (and perhaps others)

attenuator (1) region of DNA at which regulation of termination of transcription occurs, which controls the expression of some bacterial operons; (2) sequence segment located between the promoter and the first structural gene that causes partial termination of transcription

C_region constant region of immunoglobulin light and heavy chains, and T-cell receptor alpha, beta, and gamma chains; includes one or more exons depending on the particular chain

CAAT_signal CAAT box; part of a conserved sequence located about 75 bp up-stream of the start point of eukaryotic transcription units which may be involved in RNA polymerase binding; consensus=GG (C or T) CAATCT

CDS coding sequence; sequence of nucleotides that corresponds with the sequence of amino acids in a protein (location includes stop codon); feature includes amino acid conceptual translation

conflict independent determinations of the "same" sequence differ at this site or region

D-loop displacement loop; a region within mitochondrial DNA in which a short stretch of RNA is paired with one strand of DNA, displacing the original partner DNA strand in this region; also used to describe the displacement of a region of one strand of duplex DNA by a single stranded invader in the reaction catalyzed by RecA protein

D-segment diversity segment of immunoglobulin heavy chain, and T-cell receptor beta chain

enhancer a cis-acting sequence that increases the utilization of (some) eukaryotic promoters, and can function in either orientation and in any location (upstream or downstream) relative to the promoter

exon region of genome that codes for portion of spliced mRNA; may contain 5'UTR all CDSs, and 3'UTR

GC_signal GC box; a conserved GC-rich region located upstream of the start point of eukaryotic transcription units which may occur in multiple copies or in either orientation; consensus=GGGCGG

gene region of biological interest identified as a gene and for which a name has been assigned

iDNA intervening DNA; DNA which is eliminated through any of several kinds of recombination

intron a segment of DNA that is transcribed, but removed from within the transcript by splicing together the sequences (exons) on either side of it

J_segment joining segment of immunoglobulin light and heavy chains, and T-cell receptor alpha, beta, and gamma chains

LTR long terminal repeat, a sequence directly repeated at both ends of a defined sequence, of the sort typically found in retroviruses

mat_peptide mature peptide or protein coding sequence; coding sequence for the mature or final peptide or protein product following post-translational modification; the location does not include the stop codon (unlike the corresponding CDS)

misc_binding site in nucleic acid which covalently or non-covalently binds another moiety that cannot be described by any other Binding key (primer_bind or protein_bind)

misc_difference feature sequence is different from that presented in the entry and cannot be described by any other Difference key (conflict, unsure, old_sequence, mutation, variation, allele, or modified_base)

misc_feature region of biological interest which cannot be described by any other feature key; a new or rare feature

misc_recomb site of any generalized, site-specific or replicative recombination event where there is a breakage and reunion of duplex DNA that cannot be described by other recombination keys (iDNA and virion) or qualifiers of source key (/insertion_seq, /transposon, /proviral)

misc_RNA any transcript or RNA product that cannot be defined by other RNA keys (prim_transcript, precursor_RNA, mRNA, 5'clip, 3'clip, 5'UTR, 3'UTR, exon, CDS, sig_peptide, transit_peptide, mat_peptide, intron, polyA_site, rRNA, tRNA, scRNA, and snRNA)

misc_signal any region containing a signal controlling or altering gene function or expression that cannot be described by other Signal keys (promoter, CAAT_signal, TATA_signal, -35_signal, -10_signal, GC_signal, RBS, polyA_signal, enhancer, attenuator, terminator, and rep_origin)

misc_structure any secondary or tertiary structure or conformation that cannot be described by other Structure keys (stem_loop and D-loop)

modified_base the indicated nucleotide is a modified nucleotide and should be substituted for by the indicated molecule (given in the mod_base qualifier value)

mRNA messenger RNA; includes 5' untranslated region (5'UTR), coding sequences (CDS, exon) and 3' untranslated region (3'UTR)

mutation a related strain has an abrupt, inheritable change in the sequence at this location

N_region extra nucleotides inserted between rearranged immunoglobulin segments

old_sequence the presented sequence revises a previous version of the sequence at this location

polyA_signal recognition region necessary for endonuclease cleavage of an RNA transcript that is followed by polyadenylation; consensus=AATAAA

polyA_site site on an RNA transcript to which will be added adenine residues by post-transcriptional polyadenylation

precursor_RNA any RNA species that is not yet the mature RNA product; may include 5' clipped region (5'clip), 5' untranslated region (5'UTR), coding sequences (CDS, exon), intervening sequences (intron), 3' untranslated region (3'UTR), and 3' clipped region (3'clip)

prim_transcript primary (initial, unprocessed) transcript; includes 5' clipped region (5'clip), 5' untranslated region (5'UTR), coding sequences (CDS, exon), intervening sequences (intron), 3' untranslated region (3'UTR), and 3' clipped region (3' clip)

primer_bind non-covalent primer binding site for initiation of replication, transcription, or reverse transcription; includes site(s) for synthetic, for example, PCR primer elements

promoter region on a DNA molecule involved in RNA polymerase binding to initiate transcription

protein_bind non-covalent protein binding site on nucleic acid

RBS ribosome binding site

repeat_region region of genome containing repeating units

repeat_unit single repeat element

rep_origin origin of replication; starting site for duplication of nucleic acid to give two identical copies

rRNA mature ribosomal RNA; the RNA component of the ribonucleoprotein particle (ribosome) which assembles amino acids into proteins

S_region switch region of immunoglobulin heavy chains; involved in the rearrangement of heavy chain DNA leading to the expression of a different immunoglobulin class from the same B-cell

satellite many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA

scRNA small cytoplasmic RNA; any one of several small cytoplasmic RNA molecules present in the cytoplasm and (sometimes) nucleus of a eukaryote

sig_peptide signal peptide coding sequence; coding sequence for an N-terminal domain of a secreted protein; this domain is involved in attaching nascent polypeptide to the membrane; leader sequence

snRNA small nuclear RNA; any one of many small RNA species confined to the nucleus; several of the snRNAs are involved in splicing or other RNA processing reactions

source identifies the biological source of the specified span of the sequence; this key is mandatory; every entry will have, as a minimum, a single source key spanning the entire sequence; more than one source key per sequence is permissable

stem_loop hairpin; a double-helical region formed by base-pairing between adjacent (inverted) complementary sequences in a single strand of RNA or DNA

STS Sequence Tagged Site; short, single-copy DNA sequence that characterizes a mapping landmark on the genome and can be detected by PCR; a region of the genome can be mapped by determining the order of a series of STSs

TATA_signal TATA box; Goldberg-Hogness box; a conserved AT-rich septamer found about 25 bp before the start point of each eukaryotic RNA polymerase II transcript unit which may be involved in positioning the enzyme for correct initiation; consensus=TATA(A or T)A(A or T)

terminator sequence of DNA located either at the end of the transcript or adjacent to a promoter region that causes RNA polymerase to terminate transcription; may also be site of binding of repressor protein

transit_peptide transit peptide coding sequence; coding sequence for an N-terminal domain of a nuclear-encoded organellar protein; this domain is involved in post-translational import of the protein into the organelle

tRNA mature transfer RNA, a small RNA molecule (75-85 bases long) that mediates the translation of a nucleic acid sequence into an amino acid sequence

unsure author is unsure of exact sequence in this region

V_region variable region of immunoglobulin light and heavy chains, and T-cell receptor alpha, beta, and gamma chains; codes for the variable amino terminal portion; can be made up from V_segments, D_segments, N_regions, and J_segments

V_segment variable segment of immunoglobulin light and heavy chains, and T-cell receptor alpha, beta, and gamma chains; codes for most of the variable region (V_region) and the last few amino acids of the leader peptide

variation a related strain contains stable mutations from the same gene (for example, RFLPs, polymorphisms, etc.) which differ from the presented sequence at this location (and possibly others)

3'clip 3'-most region of a precursor transcript that is clipped off during processing

3'UTR region at the 3′ end of a mature transcript (following the stop codon) that is not translated into a protein

5'clip 5'-most region of a precursor transcript that is clipped off during processing

5'UTR region at the 5' end of a mature transcript (preceding the initiation codon) that is not translated into a protein

-10_signal pribnow box; a conserved region about 10 bp upstream of the start point of bacterial transcription units which may be involved in binding RNA polymerase; consensus=TAtAaT

-35_signal a conserved hexamer about 35 bp upstream of the start point of bacterial transcription units; consensus=TTGACa [ ] or TGTTGACA [ ]

Table 6: List of Feature Keys Related to Protein Sequences

Key Description

CONFLICT different papers report differing sequences

VARIANT authors report that sequence variants exist

VARSPLIC description of sequence variants produced by alternative splicing

MUTAGEN site which has been experimentally altered

MOD_RES post-translational modification of a residue

ACETYLATION N-terminal or other

AMIDATION generally at the C-terminal of a mature active peptide

BLOCKED undetermined N- or C-terminal blocking group

FORMYLATION of the N-terminal methionine

GAMMA-CARBOXYGLUTAMIC ACID HYDROXYLATION of asparagine, aspartic acid, proline or lysine

METHYLATION generally of lysine or arginine

PHOSPHORYLATION of serine, threonine, tyrosine, aspartic acid or histidine

PYRROLIDONE CARBOXYLIC ACID N-terminal glutamate which has formed an internal cyclic lactam

SULFATATION generally of tyrosine

LIPID covalent binding of a lipidic moiety

MYRISTATE myristate group attached through an amide bond to the N-terminal glycine residue of the mature form of a protein or to an internal lysine residue

PALMITATE palmitate group attached through a thioether bond to a cysteine residue or through an ester bond to a serine or threonine residue

FARNESYL farnesyl group attached through a thioether bond to a cysteine residue

GERANYL-GERANYL geranyl-geranyl group attached through a thioether bond to a cysteine residue

GPI-ANCHOR glycosyl-phosphatidylinositol (GPI) group linked to the alpha-carboxyl group of the C-terminal residue of the mature form of a protein

N-ACYL DIGLYCERIDE N-terminal cysteine of the mature form of a prokaryotic lipoprotein with an amide-linked fatty acid and a glyceryl group to which two fatty acids are linked by ester linkages

DISULFID disulfide bond; the `FROM' and `TO' endpoints represent the two residues which are linked by an intra-chain disulfide bond; if the `FROM' and `TO' endpoints are identical, the disulfide bond is an interchain one and the description field indicates the nature of the cross-link

THIOLEST thiolester bond; the `FROM' and `TO' endpoints represent the two residues which are linked by the thiolester bond

THIOETH thioether bond; the `FROM' and `TO'endpoints represent the two residues which are linked by the thioether bond

CARBOHYD glycosylation site; the nature of the carbohydrate (if known) is given in the description field

METAL binding site for a metal ion; the description field indicates the nature of the metal

BINDING binding site for any chemical group (co-enzyme, prosthetic group, etc.); the chemical nature of the group is given in the description field

SIGNAL extent of a signal sequence (prepeptide)

TRANSIT extent of a transit peptide (mitochondrial, chloroplastic, or for a microbody)

PROPEP extent of a propeptide

CHAIN extent of a polypeptide chain in the mature protein

PEPTIDE extent of a released active peptide

DOMAIN extent of a domain of interest on the sequence; the nature of that domain is given in the description field

CA_BIND extent of a calcium-binding region

DNA_BIND extent of a DNA-binding region

NP_BIND extent of a nucleotide phosphate binding region; the nature of the nucleotide phosphate is indicated in the description field

TRANSMEM extent of a transmembrane region

ZN_FING extent of a zinc finger region

SIMILAR extent of a similarity with another protein sequence; precise information, relative to that sequence is given in the description field

REPEAT extent of an internal sequence repetition

HELIX secondary structure: Helices, for example, Alpha-helix, 3(10) helix, or Pi-helix

STRAND secondary structure: Beta-strand, for example, Hydrogen bonded beta-strand, or Residue in an isolated beta-bridge

TURN secondary structure Turns, for example, H-bonded turn (3-turn, 4-turn or 5-turn)

ACT_SITE amino acid(s) involved in the activity of an enzyme

SITE any other interesting site on the sequence

INIT_MET the sequence is known to start with an initiator methionine

NON_TER the residue at an extremity of the sequence is not the terminal residue; if applied to position 1, this signifies that the first position is not the N-terminus of the complete molecule; if applied to the last position, it signifies that this position is not the C-terminus of the complete molecule; there is no description field for this key

NON_CONS non consecutive residues; indicates that two residues in a sequence are not consecutive and that there are a number of unsequenced residues between them

UNSURE uncertainties in the sequence; used to describe region(s) of a sequence for which the authors are unsure about the sequence assignment

[Annex C, Appendix 3, follows]
Annex C, Appendix 3
Specimen Sequence Listing
[Annex C-bis follows]

ANNEX C-bis
TECHNICAL REQUIREMENTS FOR THE PRESENTATION OF TABLES RELATED TO NUCLEOTIDE AND AMINO ACID SEQUENCE LISTINGS IN INTERNATIONAL PATENT APPLICATIONS UNDER THE PCT
Introduction
1. These technical requirements have been elaborated so as to provide standardization of the presentation of tables related to nucleotide and amino acid sequence listings in international patent applications. These technical requirements are intended to allow the applicant to draw up such tables in a manner which is acceptable to all receiving Offices, International Searching Authorities, International Preliminary Examining Authorities and to the International Bureau for the purposes of the international phase and to all designated and elected Offices for the purposes of the national phase.

Definition
2. For the purposes of these technical requirements, "competent Authority" is the International Searching Authority that is to carry out the international search on the international application, or the International Preliminary Examining Authority that is to carry out the international preliminary examination on the international application, or the designated/elected Office before which the processing of the international application has started.

Tables related to sequence listings
3. Tables filed in electronic form under Section 801(a) shall comply with one of the following character formats:
(i) UTF-8-encoded Unicode 3.0; or

(ii) XML format conforming to the "Application-Body" Document Type Definition referred to in Appendix I of Annex F;
at the option of the competent Authority.

4. The spatial relationships (e.g., columns and rows) of the table elements shall be maintained.

5. At the option of the competent Authority, file compression is acceptable, so long as the compressed file is in a self-extracting format that will decompress on a Personal Computer Operating system that is acceptable to the competent Authority and to the International Bureau.

6. Each table shall be contained within a separate electronic file on any electronic medium that is acceptable to the competent Authority. The file recorded on the electronic medium that is acceptable to the competent Authority shall be encoded using IBM Code Page 437, IBM Code Page 932 or a compatible code page. A compatible code page, as would be required for, for example, Japanese, Chinese, Cyrillic, Arabic, Greek or Hebrew characters, is one that assigns the Roman alphabet and numerals to the same hexadecimal positions as do the specified code pages.

7. Tables filed in electronic form may be created by any means, as long as the table on an electronic medium that is acceptable to the competent Authority is readable under a Personal Computer Operating system that is acceptable to the competent Authority and to the International Bureau.

8. If the electronic medium that is acceptable to the competent Authority is submitted after the date of filing of an application, the labels shall also include the filing date of the application and the application number.

[Annex D follows]

ANNEX D
INFORMATION FROM FRONT PAGE OF PUBLISHED INTERNATIONAL APPLICATION TO BE INCLUDED IN THE GAZETTE UNDER RULE 86.1(i)
The following information shall be extracted from the front page of the publication of the international publication for each published international application and shall, in accordance with Rule 86.1(i), appear in the corresponding entry of the Gazette:
1. as to the international publication:
1.1 the international publication number

1.2 the date of the international publication

1.3 an indication whether the following items were published in the published international application:
1.31 international search report

1.32 declaration under Article 17(2)

1.33 claims amended under Article 19(1)

1.34 statement under Article 19(1)

1.35 [Deleted]

1.36 request for rectification under the third sentence of Rule 91.3(d)

1.37 information concerning the incorporation by reference of an element or part as referred to in Rule 48.2(b)(v) 1.38 information concerning a priority claim under Rule 26 bis.2(d) 1.39 information concerning a request under Rule 26bis .3 for restoration of the right of priority 1.40 information on copies of any declaration or other evidence furnished under Rule 26 bis.3(f)

1.4 the language in which the international application was filed

1.5 the language of publication of the international application

2. as to the international application:
2.1 the title of the invention

2.2 the symbol(s) of the International Patent Classification (IPC)

2.3 the international application number

2.4 the international filing date

3. as to any priority claim:
3.1 the application number of the earlier application

3.2 the date on which the earlier application was filed

3.3 where the earlier application is:
3.31 a national application: the country in which the earlier application was filed

3.32 a regional application: the authority entrusted with the granting of regional patents under the applicable regional patent treaty and, in the case referred to in Rule 4.10(b)(ii), a country party to the Paris Convention for the Protection of Industrial Property for which that earlier application was filed

3.33 an international application: the receiving Office with which it was filed

4. as to the applicant, inventor and agent:
4.1 their name(s)

4.2 their mailing address(es)

5. as to the designated States:
5.1 their names

5.2 the indication of any wish for a regional patent

5.3 the indication that every kind of protection available is sought, unless otherwise indicated

6. as to a statement concerning non-prejudicial disclosure or exception to lack of novelty:
6.1 the date of the disclosure

6.2 the place of the disclosure

6.3 the kind of the disclosure (e.g., exhibition, scientific publication, conference reports, etc.)

6.4 the title of the exhibition, publication or conference

7. as to any indication in relation to deposited biological material furnished under Rule 13bis separately from the description:
7.1 the fact that such indication is published

7.2 the date on which the International Bureau received such indication

8. as to any declaration referred to in Rule 4.17 which was received by the International Bureau before the expiration of the time limit under Rule 26ter.1:
8.1 the fact that such a declaration was made and a reference to the applicable item in Rule 4.17 under which it was made
[Annex E follows]

ANNEX E
INFORMATION TO BE PUBLISHED IN THE GAZETTE UNDER RULE 86.1(v)
1. The time limits applicable under Articles 22 and 39 in respect of each Contracting State.

2. The list of the non-patent literature agreed upon by the International Searching Authorities for inclusion in the minimum documentation.

3. The names of the national Offices which do not wish to receive copies under Article 13(2)(c).

4. The provisions of the national laws of Contracting States concerning international-type search.

5. The text of the agreements entered into between the International Bureau and the International Searching Authorities or the International Preliminary Examining Authorities.

6. The names of the national Offices which entirely or in part waived their rights to any communication under Article 20.

7. The names of the Contracting States which are bound by Chapter II of the PCT.

8. Index of concordance of international application numbers and international publication numbers, listed according to international application numbers.

9. Index of applicants' names giving, for each name, the corresponding international publication number(s).

10. Index of international publication numbers, grouped according to the International Patent Classification symbols.

11. Indication of any subject matter that will not be searched or examined by the various International Searching and Preliminary Examining Authorities under Rules 39 and 67.

12. Requirements of designated and elected Offices under Rules 49.5 and 76.5 in relation to the furnishing of translations.

13. The dates defining the period referred to in Rule 32.1(b) during which the international application, whose effects may be extended to a successor State under Rule 32.1, must have been filed.

14. The criteria for restoration of the right of priority applied by receiving Offices under Rule 26bis .3 or designated Offices under Rule 49ter.2, and any subsequent changes in that respect.

[Annex F follows]

ANNEX F
STANDARD FOR THE FILING AND PROCESSING IN ELECTRONIC FORM OF INTERNATIONAL APPLICATIONS
[The text of Annex F, which is not reproduced here, is available from WIPO's website at http://www.wipo.org/pct/en. Annex F consists of nine main sections and four appendices, the titles of which are reproduced below.
1. Introduction

2. The E-PCT standard: Overview and vision

3. E-PCT submission structure and format

4. IA documents packaging

5. Transmission

6. Electronic filing software

7. [Deleted]

8. Principles of electronic records management

9. Abbreviated expressions, interpretation and glossary

Appendix I XML DTDs for the E-PCT Standard
Appendix II PKI Architecture for the E-PCT Standard
Appendix III Basic Common Standard for Electronic Filing
Appendix IV Use of Physical Media for the E-PCT Standard]

[End of Appendix, Annex and document]

Numeric Identifier	Numeric Identifier Description	Mandatory (M) or Optional (O)	Comment
<110>	Applicant name	M	where the name of the applicant is written in characters other than those of the Latin alphabet, the same shall also be indicated in characters of the Latin alphabet either as a mere transliteration or through translation into English
<120>	Title of Invention	M
<130>	File Reference	M, in the circumstances specified in paragraph 26 of this Standard	see paragraph 26 of this Standard
<140>	Current patent application	M, in the circumstances specified in paragraph 27 of this Standard	see paragraph 27 of this Standard; the current patent application shall be identified, in the following order, by the two-letter code indicated in accordance with WIPO Standard ST.3 and the application number (in the format used by the industrial property Office with which the current patent application is filed) or, for an international application, by the international application number
<141>	Current filing date	M, in the circumstances specified in paragraph 27 of this Standard	see paragraph 27 of this Standard; the date shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)
<150>	Earlier patent application	M, in the circumstances specified in paragraph 28 of this Standard	see paragraph 28 of this Standard; the earlier patent application shall be identified, in the following order, by the two-letter code indicated in accordance with WIPO Standard ST.3 and the application number (in the format used by the industrial property Office with which the earlier patent application was filed) or, for an international application, by the international application number
<151>	Earlier application filing date	M, in the circumstances specified in paragraph 28 of this Standard	see paragraph 28 of this Standard; the date shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)
<160>	Number of SEQ ID NOs	M
<170>	Software	O
<210>	Information for SEQ ID NO: x	M	response shall be an integer representing the SEQ ID NO shown
<211>	Length	M	sequence length expressed in number of base pairs or amino acids
<212>	Type	M	type of molecule sequenced in SEQ ID NO: x, either DNA, RNA or PRT; if a nucleotide sequence contains both DNA and RNA fragments, the value shall be "DNA"; in addition, the combined DNA/RNA molecule shall be further described in the <220> to <223> feature section
<213>	Organism	M	Genus Species (that is, scientific name) or "Artificial Sequence" or "Unknown"
<220>	Feature	M, in the circumstances specified in paragraph 29 and 30 of this Standard	leave blank; see paragraphs 29 and 30 of this Standard; description of points of biological significance in the sequence in SEQ ID NO: x) (may be repeated depending on the number of features indicated)
<221>	Name/key	M in the circumstances specified in paragraph 29 of this Standard	see paragraph 29 of this Standard; only those keys as described in Table 5 or 6 of Appendix 2 shall be used
<222>	Location	M, in the circumstances specified in paragraph 29 of this Standard	see paragraph 29 of this Standard; - from (number of first base/amino acid in the feature) - to (number of last base/amino acid in the feature) - base pairs (numbers refer to positions of base pairs in a nucleotide sequence) - amino acids (numbers refer to positions of amino acid residues in an amino acid sequence) - whether feature is located on the complementary strand to that filed in the sequence listing
<223>	Other information:	M, in the circumstances specified in paragraphs 29 and 30 of this Standard	see paragraphs 29 and 30 of this Standard; any other relevant information, using language neutral vocabulary, or free text (preferably in English); any free text is to be repeated in the main part of the description in the language thereof (see paragraph 36 of this Standard); where any modified base or modified/unusual L-amino acid appearing in Appendix 2, Tables 2 and 4, is in the sequence, the symbol associated with that base or amino acid from Appendix 2, Tables 2 and 4, should be used
<300>	Publication information	O	leave blank; repeat section for each relevant publication
<301>	Authors	O
<302>	Title	O	title of publication
<303>	Journal	O	journal name in which data published
<304>	Volume	O	journal volume in which data published
<305>	Issue	O	journal issue number in which data published
<306>	Pages	O	journal page numbers on which data published
<307>	Date	O	journal date on which data published; if possible, the date shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)
<308>	Database accession number	O	accession number assigned by database including database name
<309>	Database entry date	O	date of entry in database; the date shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)
<310>	Document number	O	document number, for patent type citations only; the full document shall specify, in the following order, the two-letter code indicated in accordance with WIPO Standard ST.3, the publication number indicated in accordance with WIPO Standard ST.6, and the kind-of-document code indicated in accordance with WIPO Standard ST.16
<311>	Filing date	O	document filing date, for patent-type citations only; the date shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)
<312>	Publication date	O	document publication date; for patent-type citations only; the date shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)
<313>	Relevant residues in SEQ ID NO: x: from to	O
<400>	Sequence	M	SEQ ID NO: x should follow the numeric identifier and should appear on the line preceding the sequence (see Appendix 3)

Symbol	Meaning	Origin of designation
a	a	a denine
g	g	g uanine
c	c	c ytosine
t	t	t hymine
u	u	u racil
r	g or a	pu r ine
y	t/u or c	p y rimidine
m	a or c	a m ino
k	g or t/u	k eto
s	g or c	s trong interactions 3H-bonds
w	a or t/u	w eak interactions 2H-bonds
b	g or c or t/u	not a
d	a or g or t/u	not c
h	a or c or t/u	not g
v	a or g or c	not t, not u
n	a or g or c or t/u, unknown, or other	a n y

Symbol	Meaning
ac4c	4-acetylcytidine
chm5u	5-(carboxyhydroxymethyl)uridine
cm	2'-O-methylcytidine
cmnm5s2u	5-carboxymethylaminomethyl-2-thiouridine
cmnm5u	5-carboxymethylaminomethyluridine
d	dihydrouridine
fm	2'-O-methylpseudouridine
gal q	beta, D-galactosylqueuosine
gm	2'-O-methylguanosine
i	inosine
i6a	N6-isopentenyladenosine
m1a	1-methyladenosine
m1f	1-methylpseudouridine
m1g	1-methylguanosine
m1i	1-methylinosine
m22g	2,2-dimethylguanosine
m2a	2-methyladenosine
m2g	2-methylguanosine
m3c	3-methylcytidine
m5c	5-methylcytidine
m6a	N6-methyladenosine
m7g	7-methylguanosine
mam5u	5-methylaminomethyluridine
mam5s2u	5-methoxyaminomethyl-2-thiouridine
man q	beta, D-mannosylqueuosine
mcm5s2u	5-methoxycarbonylmethyl-2-thiouridine
mcm5u	5-methoxycarbonylmethyluridine
mo5u	5-methoxyuridine
ms2i6a	2-methylthio-N6-isopentenyladenosine
ms2t6a	N-((9-beta-D-ribofuranosyl-2-methylthiopurine-6-yl)carbamoyl)threonine
mt6a	N-((9-beta-D-ribofuranosylpurine-6-yl)N-methylcarbamoyl)threonine
mv	uridine-5-oxyacetic acid-methylester
o5u	uridine-5-oxyacetic acid
osyw	wybutoxosine
p	pseudouridine
q	queuosine
s2c	2-thiocytidine
s2t	5-methyl-2-thiouridine
s2u	2-thiouridine
s4u	4-thiouridine
t	5-methyluridine
t6a	N-((9-beta-D-ribofuranosylpurine-6-yl)-carbamoyl)threonine
tm	2'-O-methyl-5-methyluridine
um	2'-O-methyluridine
yw	wybutosine
x	3-(3-amino-3-carboxy-propyl)uridine, (acp3)u

Symbol	Meaning
Ala	Alanine
Cys	Cysteine
Asp	Aspartic Acid
Glu	Glutamic Acid
Phe	Phenylalanine
Gly	Glycine
His	Histidine
Ile	Isoleucine
Lys	Lysine
Leu	Leucine
Met	Methionine
Asn	Asparagine
Pro	Proline
Gln	Glutamine
Arg	Arginine
Ser	Serine
Thr	Threonine
Val	Valine
Trp	Tryptophan
Tyr	Tyrosine
Asx	Asp or Asn
Glx	Glu or Gln
Xaa	unknown or other

Symbol	Meaning
Aad	2-Aminoadipic acid
bAad	3-Aminoadipic acid
bAla	beta-Alanine, beta-Aminopropionic acid
Abu	2-Aminobutyric acid
4Abu	4-Aminobutyric acid, piperidinic acid
Acp	6-Aminocaproic acid
Ahe	2-Aminoheptanoic acid
Aib	2-Aminoisobutyric acid
bAib	3-Aminoisobutyric acid
Apm	2-Aminopimelic acid
Dbu	2,4 Diaminobutyric acid
Des	Desmosine
Dpm	2,2'-Diaminopimelic acid
Dpr	2,3-Diaminopropionic acid
EtGly	N-Ethylglycine
EtAsn	N-Ethylasparagine
Hyl	Hydroxylysine
aHyl	allo-Hydroxylysine
3Hyp	3-Hydroxyproline
4Hyp	4-Hydroxyproline
Ide	Isodesmosine
aIle	allo-Isoleucine
MeGly	N-Methylglycine, sarcosine
MeIle	N-Methylisoleucine
MeLys	6-N-Methyllysine
MeVal	N-Methylvaline
Nva	Norvaline
Nle	Norleucine
Orn	Ornithine

Key	Description
allele	a related individual or strain contains stable, alternative forms of the same gene which differs from the presented sequence at this location (and perhaps others)
attenuator	(1) region of DNA at which regulation of termination of transcription occurs, which controls the expression of some bacterial operons; (2) sequence segment located between the promoter and the first structural gene that causes partial termination of transcription
C_region	constant region of immunoglobulin light and heavy chains, and T-cell receptor alpha, beta, and gamma chains; includes one or more exons depending on the particular chain
CAAT_signal	CAAT box; part of a conserved sequence located about 75 bp up-stream of the start point of eukaryotic transcription units which may be involved in RNA polymerase binding; consensus=GG (C or T) CAATCT
CDS	coding sequence; sequence of nucleotides that corresponds with the sequence of amino acids in a protein (location includes stop codon); feature includes amino acid conceptual translation
conflict	independent determinations of the "same" sequence differ at this site or region
D-loop	displacement loop; a region within mitochondrial DNA in which a short stretch of RNA is paired with one strand of DNA, displacing the original partner DNA strand in this region; also used to describe the displacement of a region of one strand of duplex DNA by a single stranded invader in the reaction catalyzed by RecA protein
D-segment	diversity segment of immunoglobulin heavy chain, and T-cell receptor beta chain
enhancer	a cis-acting sequence that increases the utilization of (some) eukaryotic promoters, and can function in either orientation and in any location (upstream or downstream) relative to the promoter
exon	region of genome that codes for portion of spliced mRNA; may contain 5'UTR all CDSs, and 3'UTR
GC_signal	GC box; a conserved GC-rich region located upstream of the start point of eukaryotic transcription units which may occur in multiple copies or in either orientation; consensus=GGGCGG
gene	region of biological interest identified as a gene and for which a name has been assigned
iDNA	intervening DNA; DNA which is eliminated through any of several kinds of recombination
intron	a segment of DNA that is transcribed, but removed from within the transcript by splicing together the sequences (exons) on either side of it
J_segment	joining segment of immunoglobulin light and heavy chains, and T-cell receptor alpha, beta, and gamma chains
LTR	long terminal repeat, a sequence directly repeated at both ends of a defined sequence, of the sort typically found in retroviruses
mat_peptide	mature peptide or protein coding sequence; coding sequence for the mature or final peptide or protein product following post-translational modification; the location does not include the stop codon (unlike the corresponding CDS)
misc_binding	site in nucleic acid which covalently or non-covalently binds another moiety that cannot be described by any other Binding key (primer_bind or protein_bind)
misc_difference	feature sequence is different from that presented in the entry and cannot be described by any other Difference key (conflict, unsure, old_sequence, mutation, variation, allele, or modified_base)
misc_feature	region of biological interest which cannot be described by any other feature key; a new or rare feature
misc_recomb	site of any generalized, site-specific or replicative recombination event where there is a breakage and reunion of duplex DNA that cannot be described by other recombination keys (iDNA and virion) or qualifiers of source key (/insertion_seq, /transposon, /proviral)
misc_RNA	any transcript or RNA product that cannot be defined by other RNA keys (prim_transcript, precursor_RNA, mRNA, 5'clip, 3'clip, 5'UTR, 3'UTR, exon, CDS, sig_peptide, transit_peptide, mat_peptide, intron, polyA_site, rRNA, tRNA, scRNA, and snRNA)
misc_signal	any region containing a signal controlling or altering gene function or expression that cannot be described by other Signal keys (promoter, CAAT_signal, TATA_signal, -35_signal, -10_signal, GC_signal, RBS, polyA_signal, enhancer, attenuator, terminator, and rep_origin)
misc_structure	any secondary or tertiary structure or conformation that cannot be described by other Structure keys (stem_loop and D-loop)
modified_base	the indicated nucleotide is a modified nucleotide and should be substituted for by the indicated molecule (given in the mod_base qualifier value)
mRNA	messenger RNA; includes 5' untranslated region (5'UTR), coding sequences (CDS, exon) and 3' untranslated region (3'UTR)
mutation	a related strain has an abrupt, inheritable change in the sequence at this location
N_region	extra nucleotides inserted between rearranged immunoglobulin segments
old_sequence	the presented sequence revises a previous version of the sequence at this location
polyA_signal	recognition region necessary for endonuclease cleavage of an RNA transcript that is followed by polyadenylation; consensus=AATAAA
polyA_site	site on an RNA transcript to which will be added adenine residues by post-transcriptional polyadenylation
precursor_RNA	any RNA species that is not yet the mature RNA product; may include 5' clipped region (5'clip), 5' untranslated region (5'UTR), coding sequences (CDS, exon), intervening sequences (intron), 3' untranslated region (3'UTR), and 3' clipped region (3'clip)
prim_transcript	primary (initial, unprocessed) transcript; includes 5' clipped region (5'clip), 5' untranslated region (5'UTR), coding sequences (CDS, exon), intervening sequences (intron), 3' untranslated region (3'UTR), and 3' clipped region (3' clip)
primer_bind	non-covalent primer binding site for initiation of replication, transcription, or reverse transcription; includes site(s) for synthetic, for example, PCR primer elements
promoter	region on a DNA molecule involved in RNA polymerase binding to initiate transcription
protein_bind	non-covalent protein binding site on nucleic acid
RBS	ribosome binding site
repeat_region	region of genome containing repeating units
repeat_unit	single repeat element
rep_origin	origin of replication; starting site for duplication of nucleic acid to give two identical copies
rRNA	mature ribosomal RNA; the RNA component of the ribonucleoprotein particle (ribosome) which assembles amino acids into proteins
S_region	switch region of immunoglobulin heavy chains; involved in the rearrangement of heavy chain DNA leading to the expression of a different immunoglobulin class from the same B-cell
satellite	many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA
scRNA	small cytoplasmic RNA; any one of several small cytoplasmic RNA molecules present in the cytoplasm and (sometimes) nucleus of a eukaryote
sig_peptide	signal peptide coding sequence; coding sequence for an N-terminal domain of a secreted protein; this domain is involved in attaching nascent polypeptide to the membrane; leader sequence
snRNA	small nuclear RNA; any one of many small RNA species confined to the nucleus; several of the snRNAs are involved in splicing or other RNA processing reactions
source	identifies the biological source of the specified span of the sequence; this key is mandatory; every entry will have, as a minimum, a single source key spanning the entire sequence; more than one source key per sequence is permissable
stem_loop	hairpin; a double-helical region formed by base-pairing between adjacent (inverted) complementary sequences in a single strand of RNA or DNA
STS	Sequence Tagged Site; short, single-copy DNA sequence that characterizes a mapping landmark on the genome and can be detected by PCR; a region of the genome can be mapped by determining the order of a series of STSs
TATA_signal	TATA box; Goldberg-Hogness box; a conserved AT-rich septamer found about 25 bp before the start point of each eukaryotic RNA polymerase II transcript unit which may be involved in positioning the enzyme for correct initiation; consensus=TATA(A or T)A(A or T)
terminator	sequence of DNA located either at the end of the transcript or adjacent to a promoter region that causes RNA polymerase to terminate transcription; may also be site of binding of repressor protein
transit_peptide	transit peptide coding sequence; coding sequence for an N-terminal domain of a nuclear-encoded organellar protein; this domain is involved in post-translational import of the protein into the organelle
tRNA	mature transfer RNA, a small RNA molecule (75-85 bases long) that mediates the translation of a nucleic acid sequence into an amino acid sequence
unsure	author is unsure of exact sequence in this region
V_region	variable region of immunoglobulin light and heavy chains, and T-cell receptor alpha, beta, and gamma chains; codes for the variable amino terminal portion; can be made up from V_segments, D_segments, N_regions, and J_segments
V_segment	variable segment of immunoglobulin light and heavy chains, and T-cell receptor alpha, beta, and gamma chains; codes for most of the variable region (V_region) and the last few amino acids of the leader peptide
variation	a related strain contains stable mutations from the same gene (for example, RFLPs, polymorphisms, etc.) which differ from the presented sequence at this location (and possibly others)
3'clip	3'-most region of a precursor transcript that is clipped off during processing
3'UTR	region at the 3′ end of a mature transcript (following the stop codon) that is not translated into a protein
5'clip	5'-most region of a precursor transcript that is clipped off during processing
5'UTR	region at the 5' end of a mature transcript (preceding the initiation codon) that is not translated into a protein
-10_signal	pribnow box; a conserved region about 10 bp upstream of the start point of bacterial transcription units which may be involved in binding RNA polymerase; consensus=TAtAaT
-35_signal	a conserved hexamer about 35 bp upstream of the start point of bacterial transcription units; consensus=TTGACa [ ] or TGTTGACA [ ]

Key	Description
CONFLICT	different papers report differing sequences
VARIANT	authors report that sequence variants exist
VARSPLIC	description of sequence variants produced by alternative splicing
MUTAGEN	site which has been experimentally altered
MOD_RES	post-translational modification of a residue
	ACETYLATION	N-terminal or other
	AMIDATION	generally at the C-terminal of a mature active peptide
	BLOCKED	undetermined N- or C-terminal blocking group
	FORMYLATION	of the N-terminal methionine
	GAMMA-CARBOXYGLUTAMIC ACID HYDROXYLATION	of asparagine, aspartic acid, proline or lysine
	METHYLATION	generally of lysine or arginine
	PHOSPHORYLATION	of serine, threonine, tyrosine, aspartic acid or histidine
	PYRROLIDONE CARBOXYLIC ACID	N-terminal glutamate which has formed an internal cyclic lactam
	SULFATATION	generally of tyrosine
LIPID	covalent binding of a lipidic moiety
	MYRISTATE	myristate group attached through an amide bond to the N-terminal glycine residue of the mature form of a protein or to an internal lysine residue
	PALMITATE	palmitate group attached through a thioether bond to a cysteine residue or through an ester bond to a serine or threonine residue
	FARNESYL	farnesyl group attached through a thioether bond to a cysteine residue
	GERANYL-GERANYL	geranyl-geranyl group attached through a thioether bond to a cysteine residue
	GPI-ANCHOR	glycosyl-phosphatidylinositol (GPI) group linked to the alpha-carboxyl group of the C-terminal residue of the mature form of a protein
	N-ACYL DIGLYCERIDE	N-terminal cysteine of the mature form of a prokaryotic lipoprotein with an amide-linked fatty acid and a glyceryl group to which two fatty acids are linked by ester linkages
DISULFID	disulfide bond; the `FROM' and `TO' endpoints represent the two residues which are linked by an intra-chain disulfide bond; if the `FROM' and `TO' endpoints are identical, the disulfide bond is an interchain one and the description field indicates the nature of the cross-link
THIOLEST	thiolester bond; the `FROM' and `TO' endpoints represent the two residues which are linked by the thiolester bond
THIOETH	thioether bond; the `FROM' and `TO'endpoints represent the two residues which are linked by the thioether bond
CARBOHYD	glycosylation site; the nature of the carbohydrate (if known) is given in the description field
METAL	binding site for a metal ion; the description field indicates the nature of the metal
BINDING	binding site for any chemical group (co-enzyme, prosthetic group, etc.); the chemical nature of the group is given in the description field
SIGNAL	extent of a signal sequence (prepeptide)
TRANSIT	extent of a transit peptide (mitochondrial, chloroplastic, or for a microbody)
PROPEP	extent of a propeptide
CHAIN	extent of a polypeptide chain in the mature protein
PEPTIDE	extent of a released active peptide
DOMAIN	extent of a domain of interest on the sequence; the nature of that domain is given in the description field
CA_BIND	extent of a calcium-binding region
DNA_BIND	extent of a DNA-binding region
NP_BIND	extent of a nucleotide phosphate binding region; the nature of the nucleotide phosphate is indicated in the description field
TRANSMEM	extent of a transmembrane region
ZN_FING	extent of a zinc finger region
SIMILAR	extent of a similarity with another protein sequence; precise information, relative to that sequence is given in the description field
REPEAT	extent of an internal sequence repetition
HELIX	secondary structure: Helices, for example, Alpha-helix, 3(10) helix, or Pi-helix
STRAND	secondary structure: Beta-strand, for example, Hydrogen bonded beta-strand, or Residue in an isolated beta-bridge
TURN	secondary structure Turns, for example, H-bonded turn (3-turn, 4-turn or 5-turn)
ACT_SITE	amino acid(s) involved in the activity of an enzyme
SITE	any other interesting site on the sequence
INIT_MET	the sequence is known to start with an initiator methionine
NON_TER	the residue at an extremity of the sequence is not the terminal residue; if applied to position 1, this signifies that the first position is not the N-terminus of the complete molecule; if applied to the last position, it signifies that this position is not the C-terminus of the complete molecule; there is no description field for this key
NON_CONS	non consecutive residues; indicates that two residues in a sequence are not consecutive and that there are a number of unsequenced residues between them
UNSURE	uncertainties in the sequence; used to describe region(s) of a sequence for which the authors are unsure about the sequence assignment

Go to MPEP - Table of Contents

	Table 1:	List of Nucleotides
	Table 2:	List of Modified Nucleotides
	Table 3:	List of Amino Acids
	Table 4:	List of Modified and Unusual Amino Acids
	Table 5:	List of Feature Keys Related to Nucleotide Sequences
	Table 6:	List of Feature Keys Related to Protein Sequences

- Appendix AI Administrative Instructions Under the PCT

Annex C, Appendix 1

Numeric Identifiers

Annex C, Appendix 2

Nucleotide and Amino Acid Symbols and Feature Table

Annex C, Appendix 3

Specimen Sequence Listing

ANNEX C-bis

TECHNICAL REQUIREMENTS FOR THE PRESENTATION OF TABLES RELATED TO NUCLEOTIDE AND AMINO ACID SEQUENCE LISTINGS IN INTERNATIONAL PATENT APPLICATIONS UNDER THE PCT

ANNEX D

INFORMATION FROM FRONT PAGE OF PUBLISHED INTERNATIONAL APPLICATION TO BE INCLUDED IN THE GAZETTE UNDER RULE 86.1(i)

ANNEX E

INFORMATION TO BE PUBLISHED IN THE GAZETTE UNDER RULE 86.1(v)

ANNEX F

STANDARD FOR THE FILING AND PROCESSING IN ELECTRONIC FORM OF INTERNATIONAL APPLICATIONS